Comparison of Fracture Resistance of Endodontically Treated Teeth Restored with Different Aesthetic Post and Core Systems Under All Ceramic Restoration Luted with Two Types of Cements

Context: Fracture of endodontically treated teeth is a grave sequela that a clinician should seriously ponder. Suitable selection of restorative materials is a requisite for long?term clinical success. Aims: To compare the fracture resistance of endodontically treated teeth restored with three different posts luted using two different cements under all ceramic crowns. Settings and Design: This in vitro study was conducted in the Department of Prosthodontics, Government Dental College, Kottayam, Kerala, India. Methods and Material: Thirty endodontically treated single?rooted mandibular premolars in which post spaces were prepared and divided into three different groups. Group 1 (n = 10): zirconia post group. Group 2 (n = 10): quartz fibre post group. Group 3 (n = 10): glass fibre post group. Each group is sub?divided into two based on the luting system: resin?modified glass ionomer cement (RMGIC) or dual?cure resin cement (DCRC). The fracture resistance testing was performed in a universal testing machine with a crosshead speed of 0.5 mm/min. Statistical Analysis Used: The mean fracture resistance were analysed using independent sample Student t?test and one?way ANOVA. Results: Within the zirconia post group, the mean fracture resistance was higher in DCRC sub?group compared to the RMGIC sub?group and the difference was statistically significant (p = 0.017). The difference in fracture resistance between three different post systems was not found to be statistically significant with respect to both the luting systems. Conclusions: It was observed that when zirconia post is used, the mean fracture resistance was higher in dual?cure resin group compared to the resin?modified GIC group.

Novel biomarkers for inborn errors of metabolism in the metabolomics era

Inborn errors of metabolism arise due to deficiency of enzymes in metabolic pathways. Recent years have seen the onset of novel technologies like proteomics, metabolomics, lipidomics, and urinomics. In the past many novel biomarkers have been developed like succinyl acetone for tyrosinemia, a number of organic acids for organic acidurias, acylcarnitines for the detection of fatty acid oxidation disorders and organic acidurias etc. With the advent of the -omics technologies, the number of novel biomarkers has increased dramatically. The use of techniques like mass spectrometry and NMR spectroscopy has led to a faster diagnosis of inborn errors of metabolism and smaller sample requirement. Hundreds of markers can be detected in a single urine sample, making diagnosis easier. There is an urgent need for implementing such techniques into routine practice in India.